The IAg7 MHC class II molecule linked to murine diabetes is a ...
The only MHC class II molecule expressed by nonobese diabetic (NOD) mice, IAg7, shares a common alphachain with IAd but has a peculiar betachain. As with most betachain alleles linked to diabetes susceptibility, IAg7 contains a nonaspartic residue at position beta57. We have produced large amounts of empty IAg7 molecules using a fly ...